Endocrine Abstracts

Introduction: Insulinomas are pancreatic endocrine tumors originating in the beta cells, characterized by hypoglycemia resulting from insulin hypersecretion.Objectives: To characterize the demography, the clinical features, imagiological findings and pathological evaluation of the cases of insulinomas identified in the previous 35 years at São João Hospital.Methods: We retrospectively analyzed the cases diagnosed as insul...

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

Diabetic ketoacidosis (DK) is one of the most serious complications of diabetes mellitus (DM). We performed a case review of DK patients admitted to the intensive care unit (ICU) of our Hospital between 1 June 2012 and 30 June 2016. A demographic analysis was made, time of DM evolution, the therapy and the factors that led to its decompensation. Thus, a total of 42 DK patients were admitted to the ICU in the referred period, mean age was 45 years, a clear predominance of femal...

Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes mellitus (DM). We describe 2 cases of type-2 diabetic patients admitted by a surgical reason/trauma in which DM control was neglected. We present a 74-year-old patient with poor metabolic control (HbA1c 7,6%) treated with metphormin, sitagliptin and glibenclamide, admitted for orthopaedic surgery. During hospitalization, there were noted several episodes of disorientation with hyperglycae...

Introduction: Thyrotoxicosis after total thyroidectomy (TT) is mostly iatrogenic. Rarely, an hyperfunctional thyroid remnant or ectopic tissue may be the cause. We report a case of Graves’s disease in a mediastinal thyroid mass presenting 7 years after TT for nontoxic goitre.Case report: A 67-year-old woman presented with palpitations, fatigue and weight loss. She had a history of TT for nontoxic multinodular goitre at the age of 60 without any sign...

Introduction: There are several endocrine causes of hyponatremia. SIADH is perhaps the most challenging, as patients do not always respond to initial correction measures and pharmacological treatment options are scarce. Urea is a viable option, but not commonly used.Methods: Analysis of patients with SIADH-induced hyponatremia (<135mEq/l) treated with urea per os in the Portuguese Institute of Oncology of Porto between August 2021 and Octobe...

Introduction: Nonislet cell tumour hypoglycemia (NICTH) is a rare complication of malignancy. The most common cause is overproduction of IGF2, which activates insulin receptors, resulting in hypoinsulinemic hypoglycemia. When a solitary fibrous tumor is responsible, it is called Doege-Potter syndrome.Case 1: 58-year-old woman, with a history of gastrointestinal stromal tumor and pleural solitary fibrous tumor with pulmonary and lymph node metastases. She...

Introduction: Bilateral adrenal masses may appear in the context of metastatic disease, adrenal congenital hyperplasia, primary tumors or infections, among others. Primary adrenal lymphoma is rare, accounting for approximately 1% of cases of non-Hodgkin lymphoma. Clinical case: 47-year-old woman, with a history of erythema nodosum and left hemithyroidectomy in the context of benign nodular disease. She presented with persistent fever and tiredne...

Introduction: Hypopituitarism is a rare diagnosis that is mainly due to primary pituitary neoplasms and their treatment. There are rarer causes such as hemorrhage/ischemia, traumatic brain injury, infections and infiltrative lesions. Clinical case: We herein present an 18-year-old male patient diagnosed with acute promyelocytic leukemia at the age of 14, with no evidence of central nervous system invasion in several lumbar punctures during his follow-up....

Introduction: Bilateral macronodular adrenal hyperplasia ACTH-independent (BMAH) represents less than 1% of the causes of Cushing’s syndrome (CS). Studies have shown that mutations in the gene ARMC5 are a common cause of family BMAH and are associated with severe clinical disease and the development of meningiomas.Case report: 64-years-old man presented to our consult due to bilateral macronodular adrenal hyperplasia. He had diabetes mellitus, arter...